Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment.
Food Chem
; 134(3): 1256-62, 2012 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-25005941
ABSTRACT
Nine anthocyanins (1-9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (8) and cyanidin (9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1-10 µM. Both delphinidin (8) and cyanidin (9) decreased the production of IL-8 in treated cells, at 1 and 10 µM, respectively. Delphinidin (8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Interleucina-8
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Doença Pulmonar Obstrutiva Crônica
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Eugenia
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Frutas
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Antocianinas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article