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Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment.
Flores, Gema; Dastmalchi, Keyvan; Paulino, Sturlainny; Whalen, Kathleen; Dabo, Abdoulaye J; Reynertson, Kurt A; Foronjy, Robert F; D'Armiento, Jeanine M; Kennelly, Edward J.
Afiliação
  • Flores G; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States; Instituto de Fermentaciones Industriales, Consejo Superior de Investigaciones Científicas (CSIC), c/Juan de la Cierva 3, 28006 Madr
  • Dastmalchi K; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
  • Paulino S; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
  • Whalen K; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States; Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10
  • Dabo AJ; Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10032, United States.
  • Reynertson KA; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
  • Foronjy RF; Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10032, United States.
  • D'Armiento JM; Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10032, United States.
  • Kennelly EJ; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
Food Chem ; 134(3): 1256-62, 2012 Oct 01.
Article em En | MEDLINE | ID: mdl-25005941
ABSTRACT
Nine anthocyanins (1-9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (8) and cyanidin (9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1-10 µM. Both delphinidin (8) and cyanidin (9) decreased the production of IL-8 in treated cells, at 1 and 10 µM, respectively. Delphinidin (8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Interleucina-8 / Doença Pulmonar Obstrutiva Crônica / Eugenia / Frutas / Antocianinas Idioma: En Ano de publicação: 2012 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Interleucina-8 / Doença Pulmonar Obstrutiva Crônica / Eugenia / Frutas / Antocianinas Idioma: En Ano de publicação: 2012 Tipo de documento: Article