Sequencing-based approach identified three new susceptibility loci for psoriasis.
Nat Commun
; 5: 4331, 2014 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-25006012
ABSTRACT
In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 10(-6). The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Psoríase
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Antígenos CD
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Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral
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Predisposição Genética para Doença
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Povo Asiático
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Fator de Transcrição Ikaros
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Subunidade p50 de NF-kappa B
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article