The role of the blood-brain barrier in the aetiology of permanent brain dysfunction in hyperphenylalaninaemia.
J Inherit Metab Dis
; 12(1): 41-6, 1989.
Article
em En
| MEDLINE
| ID: mdl-2501582
ABSTRACT
Calculations on the rate of entry of the neutral amino acids into the brain via the blood-brain barrier show that a considerable decrease in this rate, particularly for tryptophan and tyrosine, takes place in histidinaemia and tyrosinaemia, type II. These conditions are, however, not associated with mental retardation. It is therefore concluded that effects at the blood-brain barrier alone do not provide an adequate explanation for the aetiology of permanent brain dysfunction in hyperphenylalaninaemia.
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Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Encéfalo
/
Barreira Hematoencefálica
/
Erros Inatos do Metabolismo dos Aminoácidos
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article