Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome.

Kobayashi, Junko; Yoshida, Masashi; Tarui, Suguru; Hirata, Masataka; Nagai, Yusuke; Kasahara, Shingo; Naruse, Keiji; Ito, Hiroshi; Sano, Shunji; Oh, Hidemasa

Kobayashi, Junko; Yoshida, Masashi; Tarui, Suguru; Hirata, Masataka; Nagai, Yusuke; Kasahara, Shingo; Naruse, Keiji; Ito, Hiroshi; Sano, Shunji; Oh, Hidemasa.

Afiliação

Kobayashi J; Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Yoshida M; Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Tarui S; Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Hirata M; Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Nagai Y; Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Kasahara S; Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Naruse K; Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Ito H; Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Sano S; Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Oh H; Department of Regenerative Medicine, Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.

PLoS One ; 9(7): e102796, 2014.

Article em En | MEDLINE | ID: mdl-25050861

Assuntos

Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Epigênese Genética; Proteínas de Homeodomínio/genética; Síndrome do Coração Esquerdo Hipoplásico/genética; Células-Tronco Pluripotentes Induzidas/fisiologia; Receptor Notch1/genética; Fatores de Transcrição/genética; Animais; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Diferenciação Celular; Células Cultivadas; Histonas/metabolismo; Proteína Homeobox Nkx-2.5; Proteínas de Homeodomínio/metabolismo; Humanos; Síndrome do Coração Esquerdo Hipoplásico/metabolismo; Síndrome do Coração Esquerdo Hipoplásico/patologia; Camundongos Endogâmicos NOD; Camundongos SCID; Miócitos Cardíacos/metabolismo; Regiões Promotoras Genéticas; Processamento de Proteína Pós-Traducional; Receptor Notch1/metabolismo; Fatores de Transcrição/metabolismo; Transcrição Gênica

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Síndrome do Coração Esquerdo Hipoplásico / Proteínas de Homeodomínio / Epigênese Genética / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Receptor Notch1 / Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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