Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance, metabolic syndrome, and subclinical coronary atherosclerosis.
Eur J Endocrinol
; 171(3): 319-25, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25053728
ABSTRACT
BACKGROUND:
The association of subclinical hypothyroidism (SCH) with insulin resistance, metabolic syndrome (MS), and coronary atherosclerosis is uncertain.OBJECTIVE:
To investigate the role of increased intrahepatic fat in the association of SCH with insulin resistance, MS, and coronary atherosclerosis. DESIGN, PATIENTS, ANDMETHODS:
We conducted a cross-sectional study in a sample of 753 subjects (46% males) aged 35-70 years with no history of diabetes, renal, hepatic, thyroid, or coronary heart disease, and were participants of the Genetics of Atherosclerotic Disease study. SCH was defined as a high serum TSH level with normal free thyroxine concentration. Fatty liver (FL), coronary artery calcification (CAC), and abdominal visceral adipose tissue were assessed by computed tomography. Cross-sectional associations of SCH with and without FL, with MS, insulin resistance, and subclinical atherosclerosis defined as a CAC score >0, were examined in logistic regression models.RESULTS:
SCH was observed in 17.7% of the population studied. The prevalence of FL was similar in both euthyroid and SCH subjects (31.8 vs 27.8%, P=0.371). SCH plus FL subjects were heavier and had more metabolic abnormalities compared with SCH plus normal liver subjects. In multivariate-adjusted logistic regression analyses, SCH plus FL was associated with MS (odds ratio (OR) 2.73, 95% CI 1.26-5.92), insulin resistance (OR 4.91, 95% CI 1.63-14.75), and CAC score >0 (OR 3.05, 95% CI 1.20-7.76). SCH without FL showed no associations.CONCLUSION:
SCH with FL is associated with increased odds of MS, insulin resistance, and CAC, independent of potential confounders.
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Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Resistência à Insulina
/
Síndrome Metabólica
/
Fígado Gorduroso
/
Hipotireoidismo
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article