Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors.

Lockhart, Deborah E A; Schuettelkopf, Alexander; Blair, David E; van Aalten, Daan M F

Lockhart, Deborah E A; Schuettelkopf, Alexander; Blair, David E; van Aalten, Daan M F.

Afiliação

Lockhart DE; Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Schuettelkopf A; Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Blair DE; Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
van Aalten DM; Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom. Electronic address: dmfvanaalten@dundee.ac.uk.

FEBS Lett ; 588(17): 3282-90, 2014 Aug 25.

Article em En | MEDLINE | ID: mdl-25063338

Assuntos

Aspergillus fumigatus/enzimologia; Quitinases/antagonistas & inibidores; Inibidores Enzimáticos/farmacologia; Quitinases/química; Cristalografia por Raios X; Avaliação Pré-Clínica de Medicamentos; Ensaios de Triagem em Larga Escala; Concentração Inibidora 50; Cinética; Modelos Moleculares; Dados de Sequência Molecular; Conformação Proteica

Palavras-chave

Aspergillus fumigatus; Chitinases; High-throughput screen (HTS); Inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Quitinases / Inibidores Enzimáticos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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