[The role of a molecule associated with drug dependence, shati/nat8l].
Nihon Shinkei Seishin Yakurigaku Zasshi
; 33(4): 167-73, 2013 Aug.
Article
em Ja
| MEDLINE
| ID: mdl-25069253
ABSTRACT
Various molecules are involved in drug addiction induced by drugs of abuse. Therefore, the mechanism of drug addiction is still not clear, and it has been a difficulty in the development of preventive and curative drugs for drug dependence. We tried to identify the molecules associated with drug dependence, and found three molecules including shati/nat81. Recently, it has been demonstrated that the substrate for shati/nat81 is aspaltate and shati/nat8l biosynthesizes N-acetylaspartate, which exists abundantly in the mammalian brain. In this study, we investigated the physiological function of shati/nat81 and the role of shati/nat81 in drug dependence. The overexpression of shati/nat81 in the dorsal striatum of mice led to social abnormality and depression-like behavior, and worsened a part of the motor dysfunction induced by Ca2+ channel agonist BAY-K 8644. The overexpression of shati/nat81 in the nucleus accumbens of mice inhibited methamphetamine-induced behavioral and biochemical abnormalities. These findings suggest that the shati/nat81-associated system could play a role in the regulation of mental activity and motor action, and be a new target in the development of therapeutic drugs for drug dependence.
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Base de dados:
MEDLINE
Assunto principal:
Acetiltransferases
/
Transtornos Relacionados ao Uso de Substâncias
Idioma:
Ja
Ano de publicação:
2013
Tipo de documento:
Article