Asymmetric one-pot synthesis of 1,3-oxazolidines and 1,3-oxazinanes via hemiaminal intermediates.
Org Lett
; 16(16): 4098-101, 2014 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-25075467
ABSTRACT
A highly efficient method for the enantioselective one-pot synthesis of 1,3-oxazolidines and 1,3-oxazinanes has been reported. The reaction proceeds via the formation of hemiaminal intermediates obtained by the enantioselective addition of respective alcohols to imines catalyzed by a chiral magnesium phosphate catalyst, followed by intramolecular cyclization under mildly basic conditions. A wide range of substrates have been converted to the respective chiral heterocyclic products in high yields and with excellent enantioselectivities using this one-pot procedure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxazinas
/
Oxazóis
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article