Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition.

Maharjan, Sunita; Oku, Masahide; Tsuda, Masashi; Hoseki, Jun; Sakai, Yasuyoshi

Maharjan, Sunita; Oku, Masahide; Tsuda, Masashi; Hoseki, Jun; Sakai, Yasuyoshi.

Afiliação

Maharjan S; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Oku M; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Tsuda M; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Hoseki J; Research Unit for Physiological Chemistry, the Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8502, Japan.
Sakai Y; 1] Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan [2] Research Unit for Physiological Chemistry, the Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8502, Japan.

Sci Rep ; 4: 5896, 2014 Jul 31.

Article em En | MEDLINE | ID: mdl-25077633

Assuntos

Apoptose; Ácidos Borônicos/farmacologia; Mitocôndrias/metabolismo; Inibidores de Proteassoma/farmacologia; Pirazinas/farmacologia; Animais; Antioxidantes/farmacologia; Bortezomib; Células CHO; Cricetinae; Cricetulus; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Doenças Neurodegenerativas/metabolismo; Estresse Oxidativo; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteólise; Espécies Reativas de Oxigênio/metabolismo; Resveratrol; Estilbenos/farmacologia; Ubiquitinação

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Ácidos Borônicos / Apoptose / Inibidores de Proteassoma / Mitocôndrias Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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