Development of a forensic skin colour predictive test.
Forensic Sci Int Genet
; 13: 34-44, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25082135
ABSTRACT
There is growing interest in skin colour prediction in the forensic field. However, a lack of consensus approaches for recording skin colour phenotype plus the complicating factors of epistatic effects, environmental influences such as exposure to the sun and unidentified genetic variants, present difficulties for the development of a forensic skin colour predictive test centred on the most strongly associated SNPs. Previous studies have analysed skin colour variation in single unadmixed population groups, including South Asians (Stokowski et al., 2007, Am. J. Hum. Genet, 81 1119-32) and Europeans (Jacobs et al., 2013, Hum Genet. 132 147-58). Nevertheless, a major challenge lies in the analysis of skin colour in admixed individuals, where co-ancestry proportions do not necessarily dictate any one person's skin colour. Our study sought to analyse genetic differences between African, European and admixed African-European subjects where direct spectrometric measurements and photographs of skin colour were made in parallel. We identified strong associations to skin colour variation in the subjects studied from a pigmentation SNP discovery panel of 59 markers and developed a forensic online classifier based on naïve Bayes analysis of the SNP profiles made. A skin colour predictive test is described using the ten most strongly associated SNPs in 8 genes linked to skin pigmentation variation.
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Base de dados:
MEDLINE
Assunto principal:
Pigmentação da Pele
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Polimorfismo de Nucleotídeo Único
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População Negra
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População Branca
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article