Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.

Zanucco, Emanuele; El-Nikhely, Nefertiti; Götz, Rudolf; Weidmann, Katharina; Pfeiffer, Verena; Savai, Rajkumar; Seeger, Werner; Ullrich, Axel; Rapp, Ulf R

Zanucco, Emanuele; El-Nikhely, Nefertiti; Götz, Rudolf; Weidmann, Katharina; Pfeiffer, Verena; Savai, Rajkumar; Seeger, Werner; Ullrich, Axel; Rapp, Ulf R.

Afiliação

Zanucco E; Department of Molecular Biology, Max Planck Institute of Biochemistry, 85152 Martinsried, Germany,. Electronic address: zanucco@biochem.mpg.de.
El-Nikhely N; Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), 61231 Bad Nauheim, Germany, and.
Götz R; Institute for Medical Radiation and Cell Research (MSZ), University of Würzburg, 97078 Würzburg, Germany.
Weidmann K; Institute for Medical Radiation and Cell Research (MSZ), University of Würzburg, 97078 Würzburg, Germany.
Pfeiffer V; Institute for Medical Radiation and Cell Research (MSZ), University of Würzburg, 97078 Würzburg, Germany.
Savai R; Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), 61231 Bad Nauheim, Germany, and.
Seeger W; Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), 61231 Bad Nauheim, Germany, and.
Ullrich A; Department of Molecular Biology, Max Planck Institute of Biochemistry, 85152 Martinsried, Germany.
Rapp UR; Department of Molecular Biology, Max Planck Institute of Biochemistry, 85152 Martinsried, Germany,. Electronic address: Ulf.Rapp@mpi-bn.mpg.de.

J Biol Chem ; 289(39): 26804-26816, 2014 Sep 26.

Article em En | MEDLINE | ID: mdl-25096573

Assuntos

Adenoma/enzimologia; Transformação Celular Neoplásica/metabolismo; Células Epiteliais/enzimologia; Neoplasias Pulmonares/enzimologia; Sistema de Sinalização das MAP Quinases; Proteínas Proto-Oncogênicas B-raf/metabolismo; Proteínas Proto-Oncogênicas c-raf/metabolismo; Alvéolos Pulmonares/enzimologia; Mucosa Respiratória/enzimologia; Adenoma/genética; Adenoma/patologia; Animais; Transformação Celular Neoplásica/genética; Transformação Celular Neoplásica/patologia; Células Epiteliais/patologia; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Transgênicos; Mutação; Proteínas Proto-Oncogênicas B-raf/genética; Proteínas Proto-Oncogênicas c-raf/genética; Alvéolos Pulmonares/patologia; Mucosa Respiratória/patologia

Palavras-chave

Cell Biology; Lung Cancer; Mitogen-activated Protein Kinase (MAPK); Mouse Genetics; Raf Kinase; Signal Transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alvéolos Pulmonares / Adenoma / Transformação Celular Neoplásica / Proteínas Proto-Oncogênicas c-raf / Mucosa Respiratória / Sistema de Sinalização das MAP Quinases / Proteínas Proto-Oncogênicas B-raf / Células Epiteliais / Neoplasias Pulmonares Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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