Reduction of amyloid-ß deposition and attenuation of memory deficits by tolfenamic acid.
J Alzheimers Dis
; 43(2): 425-33, 2015.
Article
em En
| MEDLINE
| ID: mdl-25096618
ABSTRACT
We have previously reported that tolfenamic acid treatment decreases the amyloidogenic proteins in C57BL/6 and in old hemizygous R1.40 transgenic mice via the degradation of the transcription factor specificity 1 protein (Sp1). The lowering of amyloid-ß protein precursor (AßPP) and amyloid-ß (Aß) in hemizygous R1.40 transgenic mice was accompanied by reversal of the identified spatial reference and working memory deficits observed in the mouse model. In this study, we examined the ability of tolfenamic acid to reduce the amyloid plaque burden, as well as to ameliorate spatial learning and memory deficits in homozygous R1.40 mice. Results from immunohistochemical analysis indicated that tolfenamic acid treatment resulted in a profound decrease in cerebral Aß plaque burden that was accompanied by improvements in spatial working memory assessed by spontaneous alternation ratio in the Y-maze. These results provide further evidence that tolfenamic acid could be utilized as a repurposed drug to modify Alzheimer's disease pathogenesis.
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MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
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Peptídeos beta-Amiloides
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Ortoaminobenzoatos
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Transtornos da Memória
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article