Oxaliplatin-induced hypersensitivity reaction: underlying mechanisms and management.
J Chemother
; 27(2): 63-6, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25096819
ABSTRACT
Hypersensitivity reactions are rare but feared drugs adverse effect. These reactions are not uncommon with anticancer drugs, such as taxanes, monoclonal antibodies, and platinum compounds. Oxaliplatinum, a third-generation platinum compound, one of the mainstay drugs in the treatment of many gastrointestinal cancers, can give rise to hypersensitivity reactions, sometimes with fatal outcomes. In this paper, we reviewed the incidence and mechanisms underlying the occurrence of this event, highlighting the most recent advances concerning the pathogenesis of the reaction and also reporting possible risk factors identified and the most effective treatment in preventing the onset of this event.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organoplatínicos
/
Hipersensibilidade a Drogas
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Antineoplásicos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article