Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis.
J Med Chem
; 57(18): 7550-64, 2014 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-25101488
ABSTRACT
High-affinity, functionally potent, urea-based antagonists of CCR1 have been discovered. Modulation of PXR transactivation has revealed the selective and orally bioavailable CCR1 antagonist BMS-817399 (29), which entered clinical trials for the treatment of rheumatoid arthritis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Artrite Reumatoide
/
Ureia
/
Valina
/
Receptores CCR1
/
Descoberta de Drogas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article