Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year.
Indian J Pediatr
; 82(3): 221-4, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25120062
ABSTRACT
OBJECTIVES:
To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y.METHODS:
A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry.RESULTS:
Serum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI 0.06-51.78) (p = 0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew.CONCLUSIONS:
This hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
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Puberdade Precoce
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Compostos Benzidrílicos
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Mama
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article