PML nuclear bodies: regulation, function and therapeutic perspectives.
J Pathol
; 234(3): 289-91, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25138686
ABSTRACT
PML nuclear bodies (NBs) were first described by electron microscopy and rediscovered through their treatment-reversible disruption in a rare leukaemia. They recruit multiple partner proteins and now emerge as interferon- and oxidative stress-responsive sumoylation factories. NBs mediate interferon-induced viral restriction, enhance proteolysis, finely tune metabolism and enforce stress-induced senescence. Apart from being markers of cellular stress, PML NBs could be harnessed pharmacologically in a number of conditions, including cancer, viral infection or neurodegenerative diseases.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Proteínas Nucleares
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Proteínas Supressoras de Tumor
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Corpos de Inclusão Intranuclear
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article