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High definition plus colonoscopy combined with i-scan tone enhancement vs. high definition colonoscopy for colorectal neoplasia: A randomized trial.
Hoffman, Arthur; Loth, Linn; Rey, Johannes Wilhelm; Rahman, Fareed; Goetz, Martin; Hansen, Torsten; Tresch, Achim; Niederberger, Theresa; Galle, Peter Robert; Kiesslich, Ralf.
Afiliação
  • Hoffman A; St. Mary's Hospital, Department of Medicine, Frankfurt, Germany; 1. Medical Department, Johannes Gutenberg University Mainz, Germany. Electronic address: ahoff66286@aol.com.
  • Loth L; St. Mary's Hospital, Department of Medicine, Frankfurt, Germany.
  • Rey JW; St. Mary's Hospital, Department of Medicine, Frankfurt, Germany; 1. Medical Department, Johannes Gutenberg University Mainz, Germany.
  • Rahman F; St. Mary's Hospital, Department of Medicine, Frankfurt, Germany.
  • Goetz M; 1. Medical Department, Johannes Gutenberg University Mainz, Germany; 1. Medical Department, University of Tübingen, Germany.
  • Hansen T; Institute of Pathology, Johannes Gutenberg University Mainz, Germany; Clinic Lippe, Institute of Pathology, Detmold, Germany.
  • Tresch A; Max Planck Institute, Cologne, Germany.
  • Niederberger T; Gene Zentrum Ludwig-Maximilians-Universität München, Germany.
  • Galle PR; 1. Medical Department, Johannes Gutenberg University Mainz, Germany.
  • Kiesslich R; St. Mary's Hospital, Department of Medicine, Frankfurt, Germany; 1. Medical Department, Johannes Gutenberg University Mainz, Germany.
Dig Liver Dis ; 46(11): 991-6, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25151550
BACKGROUND: High definition endoscopy is the accepted standard in colonoscopy. However, an important problem is missed polyps. AIMS: Our objective was to assess the additional adenoma detection rate between high definition colonoscopy with tone enhancement (digital chromoendoscopy) vs. white light high definition colonoscopy. METHODS: In this prospective randomized trial patients were included to undergo a tandem colonoscopy. The first exam was a white light colonoscopy with removal of all visualized polyps. The second examination was randomly assigned in a 1:1 ratio as either again white light colonoscopy (Group A) or colonoscopy with tone enhancement (Group B). Primary endpoint was the adenoma detection rate during the second withdrawal (sample size calculation - 40 per group). RESULTS: 67 lesions (Group A: n=34 vs. Group B: n=33) in 80 patients (mean age 61 years, male 64%) were identified on the first colonoscopy. The second colonoscopy detected 78 additional lesions: n=60 with tone enhancement vs. n=18 with white light endoscopy (p<0.001). Tone enhancement found more additional adenomas (A n=20 vs. B n=6, p=0.006) and identified significantly more missed adenomas per subject (0.5 vs. 0.15, p=0.006). CONCLUSIONS: High definition plus colonoscopy with tone enhancement detected more adenomas missed by white light colonoscopy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Sinais Assistido por Computador / Interpretação de Imagem Assistida por Computador / Neoplasias Colorretais / Adenocarcinoma / Colonoscopia Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Sinais Assistido por Computador / Interpretação de Imagem Assistida por Computador / Neoplasias Colorretais / Adenocarcinoma / Colonoscopia Idioma: En Ano de publicação: 2014 Tipo de documento: Article