Telomere length and mortality following a diagnosis of ovarian cancer.
Cancer Epidemiol Biomarkers Prev
; 23(11): 2603-6, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25159293
ABSTRACT
BACKGROUND:
Telomeres are essential for the maintenance of chromosomal integrity. Telomere shortening leads to genomic instability, which is hypothesized to play a role in cancer development and prognosis. No studies to date have evaluated the prognostic significance of telomere length for ovarian cancer.METHODS:
We examined whether relative telomere length in peripheral blood leukocytes was associated with survival following a diagnosis of ovarian cancer. We analyzed data from a large population-based study of incident ovarian cancer conducted in Ontario between 1995 and 2004. Telomere length was measured using the quantitative PCR-based relative telomere length assay and vital status was determined by computerized record linkage and by chart review (n = 1,042). Proportional hazard models were used to estimate ovarian cancer-specific survival HRs and 95% confidence intervals (CI) associated with quartiles of telomere length z score.RESULTS:
We found no significant relationship between telomere length and ovarian cancer-specific mortality (P log-rank test = 0.55). Compared with women in the lowest quartile of telomere length z score, the HR for women in the highest three quartiles of telomere length z score combined was 0.88 (95% CI, 0.77-1.10). The corresponding estimates for serous and nonserous tumors were 0.68 (95% CI, 0.66-1.13) and 1.13 (95% CI, 0.71-1.79), respectively.CONCLUSIONS:
Our data provide preliminary evidence that telomere length likely does not predict outcome after a diagnosis of ovarian cancer. IMPACT This represents the first study to suggest no prognostic role of telomere length for ovarian cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Telômero
/
Encurtamento do Telômero
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article