Immunity, inflammation, and vaccines for Helicobacter pylori.
Helicobacter
; 19 Suppl 1: 19-26, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25167941
ABSTRACT
Helicobacter pylori colonizes mucosa, activates Toll-like and Nod-like receptors, and usually elicits a gastric T-helper 1/17 (Th1/Th17) type of immune response. Among several bacterial factors, the secreted peptidyl prolyl cis, trans-isomerase of H. pylori represents a key factor driving Th17 inflammation. A complex and fascinating balance between H. pylori and host factors takes part in the gastric niche and is responsible for the chronicity of the infection. Novel insights into the innate and adaptive responses against H. pylori, dealing with gastric epithelial cells, cytokines, and immune evasion have been elucidated over the past year and are discussed for the development of an effective vaccine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas Bacterianas
/
Helicobacter pylori
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Infecções por Helicobacter
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article