High and ultra-high b-value diffusion-weighted imaging in prostate cancer: a quantitative analysis.
Acta Radiol
; 56(8): 1009-15, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25168023
ABSTRACT
BACKGROUND:
Diffusion-weighted imaging (DWI) is routinely used in magnetic resonance imaging (MRI) of prostate cancer. However, the routine use of b values higher than 1000 s/mm(2) is not clear up to present. Moreover, the complex diffusion behavior of malignant and benign prostate tissues hampers precise predictions of contrast in DWI images and apparent diffusion coefficient (ADC) maps.PURPOSE:
To quantitatively analyze DWI with different b values in prostate cancer and to identify b values best suitable for cancer detection. MATERIAL ANDMETHODS:
Forty-one patients with histologically proven prostate cancer were examined with high resolution T2-weighted imaging and DWI at 3 Tesla. Five different b values (0, 800, 1000, 1500, 2000 s/mm(2)) were applied. ADC values of tumors and reference areas were measured on ADC maps derived from different pairs of b values. Furthermore, signal intensities of DW images of tumors and reference areas were measured. For analysis, contrast ratios of ADC values and signal intensities of DW images were calculated and compared.RESULTS:
No significant differences were found between contrast ratios measured on ADC maps of all analyzed b value pairs (P = 0.43). Contrast ratios calculated from signal intensities of DW images were highest at b values of 1500 and 2000 s/mm(2) and differed significantly from contrast ratios at b values of 800 and 1000 s/mm(2) (P < 0.01).CONCLUSION:
Whereas contrast in ADC maps does not significantly change with different b values, contrast ratios of DW images are significantly higher at b-values of 1500 and 2000 s/mm(2) in comparison to b values of 800 and 1000 s/mm(2). Therefore, diagnostic performance of DWI in prostate cancer might be increased by application of b values higher than 1000 s/mm(2).Palavras-chave
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MEDLINE
Assunto principal:
Neoplasias da Próstata
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Algoritmos
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Interpretação de Imagem Assistida por Computador
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Aumento da Imagem
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Imagem de Difusão por Ressonância Magnética
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article