The dynamics of NF-κB pathway regulated by circadian clock.
Math Biosci
; 260: 47-53, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25172045
ABSTRACT
The circadian clock regulates many physiological parameters involving immune response to infectious agents, which is mediated by activation of the transcription factor NF-κB. Thus, understanding the NF-κB dynamics regulated by circadian clocks will help in developing better therapeutics. To this end, we proposed a detailed model in the present work on the basis of understanding inflammatory response under control from circadian clocks. Our results show that the frequencies and amplitudes of the NF-κB oscillation are dependent on the strength and modes of coupling to circadian clock. This circadian control of NF-κB pathway can therefore serve as a useful mechanism in keeping the system in check and controlling inflammatory response induced by infection and other agents. The results are consistent with earlier experimental findings.
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MEDLINE
Assunto principal:
Transdução de Sinais
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NF-kappa B
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Relógios Circadianos
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Inflamação
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Modelos Teóricos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article