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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
Bago, Ruzica; Malik, Nazma; Munson, Michael J; Prescott, Alan R; Davies, Paul; Sommer, Eeva; Shpiro, Natalia; Ward, Richard; Cross, Darren; Ganley, Ian G; Alessi, Dario R.
Afiliação
  • Bago R; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Malik N; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Munson MJ; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Prescott AR; †Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Davies P; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Sommer E; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Shpiro N; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Ward R; ‡Oncology iMED, AstraZeneca, Alderley Park, Cheshire SK10 4TG, U.K.
  • Cross D; ‡Oncology iMED, AstraZeneca, Alderley Park, Cheshire SK10 4TG, U.K.
  • Ganley IG; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Alessi DR; *MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Biochem J ; 463(3): 413-27, 2014 Nov 01.
Article em En | MEDLINE | ID: mdl-25177796
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Serina-Treonina Quinases / Classe III de Fosfatidilinositol 3-Quinases / Aminopiridinas Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Serina-Treonina Quinases / Classe III de Fosfatidilinositol 3-Quinases / Aminopiridinas Idioma: En Ano de publicação: 2014 Tipo de documento: Article