Low complements and high titre of anti-Sm antibody as predictors of histopathologically proven silent lupus nephritis without abnormal urinalysis in patients with systemic lupus erythematosus.
Rheumatology (Oxford)
; 54(3): 405-12, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25183834
ABSTRACT
OBJECTIVE:
The aim of this study was to clarify the clinical characteristics and predictors of silent LN (SLN), a type of LN in SLE without abnormal urinalysis or renal impairment.METHODS:
Of 182 patients who underwent renal biopsy, 48 did not present with abnormal urinalysis or renal impairment at the time of biopsy. The patients with LN (SLN group, n = 36) and those without LN (non-LN group, n = 12) were compared with respect to their baseline characteristics. Bivariate analysis comprised Fisher's exact test and the Mann-Whitney test, whereas multivariate analysis employed binomial logistic regression analysis.RESULTS:
LN was histopathologically identified in 36 of 48 patients. According to the International Society of Nephrology/Renal Pathology Society classification, 72% of the SLN patients were classified as having class I/II, with a further 17% having class III/IV. Bivariate analyses indicated that platelet count, serum albumin, complement components (C3 and C4), complement haemolytic activity (CH50), anti-Sm antibody titre and anti-ribonucleoprotein antibody titre were significantly different between groups. Multivariate analysis indicated that CH50 and C3 titres were significantly lower in the SLN group, whereas anti-Sm antibody titre was significantly higher. The cut-off titre, calculated based on the receiver operating characteristic curve for CH50, was 33 U/ml, with a sensitivity and specificity of 89% and 83%, respectively. The cut-off titre for anti-Sm antibodies was 9 U/ml, with a sensitivity and specificity of 74% and 83%, respectively.CONCLUSION:
Low titres of CH50 and C3 and a high titre of anti-Sm antibody were identified as predictors of SLN.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Nefrite Lúpica
/
Proteínas do Sistema Complemento
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Anticorpos Anti-Idiotípicos
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Proteínas Centrais de snRNP
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Lúpus Eritematoso Sistêmico
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article