Determining pancreatic ß-cell compensation for changing insulin sensitivity using an oral glucose tolerance test.

Solomon, Thomas P J; Malin, Steven K; Karstoft, Kristian; Knudsen, Sine H; Haus, Jacob M; Laye, Matthew J; Pedersen, Maria; Pedersen, Bente K; Kirwan, John P

Solomon, Thomas P J; Malin, Steven K; Karstoft, Kristian; Knudsen, Sine H; Haus, Jacob M; Laye, Matthew J; Pedersen, Maria; Pedersen, Bente K; Kirwan, John P.

Afiliação

Solomon TP; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark; thomas.solomon@sund.ku.dk.
Malin SK; Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio;
Karstoft K; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark;
Knudsen SH; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark;
Haus JM; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois; and.
Laye MJ; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark;
Pedersen M; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark;
Pedersen BK; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark;
Kirwan JP; Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Metabolic Translational Research Center, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio.

Am J Physiol Endocrinol Metab ; 307(9): E822-9, 2014 Nov 01.

Article em En | MEDLINE | ID: mdl-25184989

Assuntos

Alostase; Diabetes Mellitus Tipo 2/diagnóstico; Intolerância à Glucose/diagnóstico; Resistência à Insulina; Células Secretoras de Insulina/metabolismo; Insulina/metabolismo; Estado Pré-Diabético/diagnóstico; Glicemia/análise; Estudos de Coortes; Dinamarca; Diabetes Mellitus Tipo 2/sangue; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/fisiopatologia; Diagnóstico Diferencial; Progressão da Doença; Feminino; Técnica Clamp de Glucose; Intolerância à Glucose/sangue; Intolerância à Glucose/metabolismo; Intolerância à Glucose/fisiopatologia; Teste de Tolerância a Glucose; Hemoglobinas Glicadas/análise; Humanos; Insulina/sangue; Secreção de Insulina; Masculino; Pessoa de Meia-Idade; Ohio; Estado Pré-Diabético/sangue; Estado Pré-Diabético/metabolismo; Estado Pré-Diabético/fisiopatologia

Palavras-chave

disposition index; hyperinsulinemic euglycemic clamp; insulin resistance; insulin secretion; insulin sensitivity; insulin sensitivity index; obesity; oral glucose tolerance; type 2 diabetes; ß-cell dysfunction; ß-cell function

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Resistência à Insulina / Intolerância à Glucose / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Alostase / Insulina Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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