H2Me-do2pa: an attractive chelator with fast, stable and inert (nat)Bi³âº and ²¹³Bi³âº complexation for potential α-radioimmunotherapy applications.
Chem Commun (Camb)
; 50(82): 12371-4, 2014 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-25187173
ABSTRACT
The complexation properties of H2Me-do2pa towards (nat)Bi(3+) reveal a rather fast formation of the [Bi(Me-do2pa)](+) complex, which is endowed with a very high thermodynamic stability (log K(BiL) = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with (213)Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to taken here as a reference.
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1
Base de dados:
MEDLINE
Assunto principal:
Bismuto
/
Quelantes
/
Complexos de Coordenação
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article