The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively.

Al-Sabah, Suleiman; Al-Fulaij, Munya; Shaaban, Ghina; Ahmed, Hanadi A; Mann, Rosalind J; Donnelly, Dan; Bünemann, Moritz; Krasel, Cornelius

Al-Sabah, Suleiman; Al-Fulaij, Munya; Shaaban, Ghina; Ahmed, Hanadi A; Mann, Rosalind J; Donnelly, Dan; Bünemann, Moritz; Krasel, Cornelius.

Afiliação

Al-Sabah S; Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Al-Fulaij M; Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Shaaban G; Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Ahmed HA; Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Mann RJ; School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Donnelly D; School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Bünemann M; School of Pharmacy, Institute for Pharmacology and Toxicology, The Philipps University of Marburg, Marburg, Germany.
Krasel C; School of Pharmacy, Institute for Pharmacology and Toxicology, The Philipps University of Marburg, Marburg, Germany.

PLoS One ; 9(9): e106890, 2014.

Article em En | MEDLINE | ID: mdl-25191754

Assuntos

Arrestinas/metabolismo; Quinase 2 de Receptor Acoplado a Proteína G/metabolismo; Receptor do Peptídeo Semelhante ao Glucagon 1/metabolismo; Receptores dos Hormônios Gastrointestinais/metabolismo; Animais; Células CHO; Cricetinae; Cricetulus; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Polipeptídeo Inibidor Gástrico/metabolismo; Polipeptídeo Inibidor Gástrico/farmacologia; Peptídeo 1 Semelhante ao Glucagon/metabolismo; Peptídeo 1 Semelhante ao Glucagon/farmacologia; Receptor do Peptídeo Semelhante ao Glucagon 1/agonistas; Receptor do Peptídeo Semelhante ao Glucagon 1/genética; Células HEK293; Humanos; Ligação Proteica; Receptores dos Hormônios Gastrointestinais/agonistas; Receptores dos Hormônios Gastrointestinais/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores dos Hormônios Gastrointestinais / Arrestinas / Quinase 2 de Receptor Acoplado a Proteína G / Receptor do Peptídeo Semelhante ao Glucagon 1 Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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