Influence of agonist induced internalization on [3H]Ro15-4513 binding-an application to imaging fluctuations in endogenous GABA with positron emission tomography.
Synapse
; 69(1): 60-5, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25196273
ABSTRACT
Low affinity α1/α2 containing GABAA receptors are significantly less able to bind [(11) C]/[(3) H]Ro15-4513 following translocation to the endosomal environment. The alterations in [(11) C]Ro15-4513 binding observed in vivo following perturbations in endogenous GABA are likely driven by both alterations in receptor binding parameters following agonist induced internalisation and the GABA Shift.
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Base de dados:
MEDLINE
Assunto principal:
Azidas
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Benzodiazepinas
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Compostos Radiofarmacêuticos
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Antagonistas de Receptores de GABA-A
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Ácido gama-Aminobutírico
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Hipocampo
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Ácidos Nipecóticos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article