The development of ovarian hyperstimulation syndrome in the implementation of assisted reproductive technology in women with a background of endocrine pathology.
Gynecol Endocrinol
; 30 Suppl 1: 25-9, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25200824
ABSTRACT
UNLABELLED Known factors of the development of ovarian hyperstimulation syndrome (OHSS) are not informative enough, if considered independently. This is confirmed by the absence of initial predictors in cases of severe OHSS and, in contrast, not clinically apparent manifestations in patients seemingly having high risk of this pathology. These circumstances demand investigation of additional prognostic parameters of the OHSS. PURPOSE:
To find out additional OHSS risk factors alongside with the previously known ones in the course of implementation of assisted reproductive technologies (ART) in patients having initial metabolic and hormonal disorders. INVESTIGATION DATA ANDMETHODS:
Retrospective analysis of clinical laboratory and functional parameters of hormonal and metabolic state of 133 women suffering OHSS was held. Classification by Schenker, 1995, was used to detect the diagnosis. Control group consisted of 347 women with the unverified OHSS. Basic and control study groups were similar in age and in number of mild and long protocols of ovarian stimulation held. RESULTS AND THEIRDISCUSSION:
A significant correlation dependence was revealed between the fact of the OHSS development and some indicators of hormonal and metabolic state HOMA index of insulin resistance; thyroid parameters thyroid stimulating hormone (TSH), free thyroxine (fT4), thyroid peroxidase antibodies (AbTPO); and level of prolactin. The revealed correlation dependence of the OHSS development on the above parameters allows to use them for determination of the OHSS risk group and taking measures to prevent this complication of the ART.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Indução da Ovulação
/
Síndrome de Hiperestimulação Ovariana
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article