Unprecedented 1,14-seco-crotofolanes from Croton insularis: oxidative cleavage of crotofolin C by a putative homo-Baeyer-Villiger rearrangement.
Chemistry
; 20(44): 14226-30, 2014 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-25233878
ABSTRACT
EBC-162 isolated from Croton insularis, obtained from the northern rainforest of Australia, was structurally affirmed as crotofolinâ
C (4). Novel oxidative degradation products, EBC-233 and EBC-300, which are the first crotofolane endoperoxides, were also isolated. Both endoperoxides were found to be stable intermediates, which are proposed to undergo an unprecedented homo-Baeyer-Villiger biosynthetic rearrangement to give a new class of 1,14-seco-crotofolane diterpenes. Prolonged storage of all isolates assisted in authenticating their natural product status. Anticancer activities of reported compounds are presented.
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Base de dados:
MEDLINE
Assunto principal:
Croton
/
Diterpenos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article