Alteration of lipid parameters in patients with subclinical hypothyroidism.
Int J Endocrinol Metab
; 12(3): e17496, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-25237326
ABSTRACT
BACKGROUND:
Overt hypothyroidism is associated with abnormalities of lipid metabolism, but conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (SCH) exist.OBJECTIVES:
The aim of this study was to assess differences in lipid profile parameters between subjects with and without SCH in a north Indian population. PATIENTS ANDMETHODS:
Serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were evaluated in a cross-sectional study.RESULTS:
Mean serum total cholesterol (TC), triglycerides (TG) and very low-density cholesterol (VLDL) were significantly higher in patients with SCH than controls (P < 0.05). Mean TC, TG and low-density cholesterol (LDL) concentrations were higher in patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L than those with serum TSH equal to or less than 10 mU/L, but this difference was not statistically significant. No association was found between serum high-density cholesterol (HDL-C) concentration and serum TSH level.CONCLUSIONS:
High TC, TG and VLDL were observed in our patients with SCH.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article