Impact of drug shortages on patients receiving parenteral nutrition after laparotomy.
JPEN J Parenter Enteral Nutr
; 38(2 Suppl): 65S-71S, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25239113
ABSTRACT
BACKGROUND:
Drug shortages, including parenteral nutrition (PN) product shortages, continue to increase and have a significant impact on healthcare. The extent to which product shortages affect bowel recovery and outcomes in patients receiving PN is unknown. The objective of this study is to examine the impact of extensive PN product shortages on patients receiving PN after laparotomy for bowel obstruction.METHODS:
A retrospective review was conducted for patients who underwent a laparotomy for small bowel obstruction and received PN postoperatively. Periods of limited and extensive PN product shortages at our institution were defined. PN therapy duration and composition, daily laboratory values, electrolyte supplementation, length of stay, and cost of hospitalization were recorded. Analyses using χ(2), Wilcoxon rank sum, log-rank, and t tests as appropriate were performed using SAS/STAT 9.2.RESULTS:
Patients had longer hospital length of stays (20.0 vs 15.2 days; P = .04), trends toward longer PN therapy courses (8.8 vs 6.6 days; P = .13), and a 51% higher hospital cost during the extensive PN drug shortage period. Mean serum electrolyte concentrations were similar while the need for supplemental magnesium replacements increased during the extensive shortage period (75% vs 35%; P = .01). Supplemented patients also required higher doses of magnesium (2.7 vs 1.0 g; P < .01) and more laboratory draws during the extensive shortage period (59% vs 21% required ≥ 2 draws daily; P = .04). Fewer lipid calories were delivered during the extensive shortage period (2.4 vs 4.8 kcal/kg/d; P < .01).CONCLUSION:
PN drug shortages have a negative impact on patient outcomes and require aggressive management strategies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Cuidados Pós-Operatórios
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Procedimentos Cirúrgicos do Sistema Digestório
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Preparações Farmacêuticas
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Nutrição Parenteral
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Custos Hospitalares
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Obstrução Intestinal
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Tempo de Internação
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article