The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-ß (Aß) aggregation.

Benilova, Iryna; Gallardo, Rodrigo; Ungureanu, Andreea-Alexandra; Castillo Cano, Virginia; Snellinx, An; Ramakers, Meine; Bartic, Carmen; Rousseau, Frederic; Schymkowitz, Joost; De Strooper, Bart

Benilova, Iryna; Gallardo, Rodrigo; Ungureanu, Andreea-Alexandra; Castillo Cano, Virginia; Snellinx, An; Ramakers, Meine; Bartic, Carmen; Rousseau, Frederic; Schymkowitz, Joost; De Strooper, Bart.

Afiliação

Benilova I; From the VIB Center for the Biology of Disease, the Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, University of Leuven.
Gallardo R; the VIB Switch Laboratory, the Switch Laboratory, Department of Cellular and Molecular Medicine.
Ungureanu AA; Laboratory of Solid State Physics and Magnetism, University of Leuven, 3000 Leuven, and Imec, 3001 Leuven, Belgium.
Castillo Cano V; the VIB Switch Laboratory, the Switch Laboratory, Department of Cellular and Molecular Medicine.
Snellinx A; From the VIB Center for the Biology of Disease, the Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, University of Leuven.
Ramakers M; the VIB Switch Laboratory, the Switch Laboratory, Department of Cellular and Molecular Medicine.
Bartic C; Laboratory of Solid State Physics and Magnetism, University of Leuven, 3000 Leuven, and Imec, 3001 Leuven, Belgium.
Rousseau F; the VIB Switch Laboratory, the Switch Laboratory, Department of Cellular and Molecular Medicine.
Schymkowitz J; the VIB Switch Laboratory, the Switch Laboratory, Department of Cellular and Molecular Medicine.
De Strooper B; From the VIB Center for the Biology of Disease, the Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, University of Leuven, bart.destrooper@cme.vib-kuleuven.be.

J Biol Chem ; 289(45): 30977-89, 2014 Nov 07.

Article em En | MEDLINE | ID: mdl-25253695

Assuntos

Doença de Alzheimer/genética; Peptídeos beta-Amiloides/química; Precursor de Proteína beta-Amiloide/genética; Fragmentos de Peptídeos/química; Doença de Alzheimer/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Benzotiazóis; Encéfalo/metabolismo; Técnicas de Cultura de Células/métodos; Linhagem Celular; Cricetinae; Modelos Animais de Doenças; Humanos; Cinética; Camundongos; Camundongos Endogâmicos C57BL; Mutagênese; Mutação; Neurônios/citologia; Neurônios/metabolismo; Solubilidade; Termodinâmica; Tiazóis/química

Palavras-chave

Aggregation; Alzheimer Disease; Amyloid-ß (Aß); Kinetics; Thermodynamics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Doença de Alzheimer Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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