Evaluation of the recombinant tissue plasminogen activator pretreatment in acute stroke patients with large vessel occlusions treated with the direct bridging approach. Is it worth the effort?
Eur J Neurol
; 22(2): 322-7, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25258016
ABSTRACT
BACKGROUND AND PURPOSE:
The direct bridging concept in acute stroke treatment combines intravenous thrombolysis (IVT) and endovascular treatment (EVT). The frequency and extent of reperfusion obtained already due to IVT were evaluated. Additionally undesired events and the clinical outcome were analysed.METHODS:
Fifty-seven acute stroke patients treated with direct bridging were analysed for this study. The response to IVT was evaluated according to the modified Thrombolysis in Cerebral Infarction scale (m-TICI). IVT responders (m-TICI ≥2B in digital subtraction angiography) were compared with IVT non-responders (m-TICI <2B in digital subtraction angiography) with respect to clinical outcome and occurrence of undesired events.RESULTS:
Fourteen patients (25%) got a change from TICI 0 to ≥2B due to IVT alone. There were otherwise no differences between the IVT responders and IVT non-responders.CONCLUSIONS:
Intravenous thrombolysis pretreatment in the context of the bridging approach contributes substantially to revascularization.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Terapia Trombolítica
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Isquemia Encefálica
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Circulação Cerebrovascular
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Avaliação de Resultados em Cuidados de Saúde
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Ativador de Plasminogênio Tecidual
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Acidente Vascular Cerebral
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Fibrinolíticos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article