Graft versus leukemia response without graft-versus-host disease elicited by adoptively transferred multivirus-specific T-cells.
Mol Ther
; 23(1): 179-83, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25266309
ABSTRACT
A 12-year-old boy with refractory acute lymphoblastic leukemia received a haploidentical transplant from his mother. As prophylaxis for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and adenovirus, he received ex vivo expanded virus-specific donor T cells 3.5 months after transplant. Four weeks later leukemic blasts bearing the E2A deletion, identified by fluorescent in situ hybridization (FISH), appeared transiently in the blood followed by a FISH-negative hematological remission, which was sustained until a testicular relapse 3.5 months later. Clearance of the circulating leukemic cells coincided with a marked increase in circulating virus-specific T cells. The virus-specific cytotoxic T-cell (CTL) line showed strong polyfunctional reactivity with the patient's leukemic cells but not phytohemagglutinin (PHA) blasts, suggesting that virus-specific CTL lines may have clinically significant antileukemia activity.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
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Imunoterapia Adotiva
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Transplante de Medula Óssea
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Efeito Enxerto vs Leucemia
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Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article