Your browser doesn't support javascript.
loading
Longitudinal assessment of concurrent changes in left ventricular ejection fraction and left ventricular myocardial tissue characteristics after administration of cardiotoxic chemotherapies using T1-weighted and T2-weighted cardiovascular magnetic resonance.
Jordan, Jennifer H; D'Agostino, Ralph B; Hamilton, Craig A; Vasu, Sujethra; Hall, Michael E; Kitzman, Dalane W; Thohan, Vinay; Lawrence, Julia A; Ellis, Leslie R; Lash, Timothy L; Hundley, W Gregory.
Afiliação
  • Jordan JH; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • D'Agostino RB; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Hamilton CA; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Vasu S; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Hall ME; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Kitzman DW; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Thohan V; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Lawrence JA; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Ellis LR; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Lash TL; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
  • Hundley WG; From the Departments of Internal Medicine (Section on Cardiovascular Medicine) (J.H.J., S.V., M.E.H., D.W.K., V.T., W.G.H.), Public Health Sciences (R.B.D., T.L.L.), Biomedical Engineering (C.A.H.), Internal Medicine (Hematology and Oncology Section) (J.A.L., L.R.E.), and Radiology (W.G.H.), Wake Fo
Circ Cardiovasc Imaging ; 7(6): 872-9, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25273568
ABSTRACT

BACKGROUND:

In a murine anthracycline-related cardiotoxicity model, increases in cardiovascular magnetic resonance myocardial contrast-enhanced T1-weighted signal intensity are associated with myocellular injury and decreases with left ventricular ejection fraction. We sought to determine whether T1- and T2-weighted measures of signal intensity associate with decreases in left ventricular ejection fraction in human subjects receiving potentially cardiotoxic chemotherapy. METHODS AND

RESULTS:

In 65 individuals with breast cancer (n=51) or a hematologic malignancy (n=14), we measured left ventricular volumes, ejection fraction, and contrast-enhanced T1-weighted and T2-weighted signal intensity before and 3 months after initiating potentially cardiotoxic chemotherapy using blinded, unpaired analysis of cardiovascular magnetic resonance images. Participants were aged 51 ± 12 years, of whom 55% received an anthracycline, 38% received a monoclonal antibody, and 6% received an antimicrotubule agent. Overall, left ventricular ejection fraction decreased from 57 ± 6% to 54 ± 7% (P<0.001) because of an increase in end-systolic volume (P<0.05). T1-weighted signal intensities also increased from 14.1 ± 5.1 to 15.9 ± 6.8 (P<0.05), with baseline values trending higher among individuals who received chemotherapy before study enrollment (P=0.06). Changes in T1-weighted signal intensity did not differ within the 17 LV myocardial segments (P=0.97). Myocardial edema quantified from T2-weighted images did not change significantly after 3 months (P=0.70).

CONCLUSIONS:

Concordant with previous animal studies, cardiovascular magnetic resonance measures of contrast-enhanced T1-weighted signal intensity occur commensurate with small but significant left ventricular ejection fraction declines 3 months after the receipt of potentially cardiotoxic chemotherapy. These data indicate that changes in T1-weighted signal intensity may serve as an early marker of subclinical injury related to the administration of potentially cardiotoxic chemotherapy in human subjects.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Volume Sistólico / Neoplasias da Mama / Imageamento por Ressonância Magnética / Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Antraciclinas / Neoplasias Hematológicas / Moduladores de Tubulina / Ventrículos do Coração / Antibióticos Antineoplásicos Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Volume Sistólico / Neoplasias da Mama / Imageamento por Ressonância Magnética / Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Antraciclinas / Neoplasias Hematológicas / Moduladores de Tubulina / Ventrículos do Coração / Antibióticos Antineoplásicos Idioma: En Ano de publicação: 2014 Tipo de documento: Article