Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy.

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Jiang, Min; Gao, Xu; Rubinstein, Jack; Wieczorek, David F; Shull, Gary E

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Jiang, Min; Gao, Xu; Rubinstein, Jack; Wieczorek, David F; Shull, Gary E.

Afiliação

Prasad V; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: prasad.vikram@gmail.com.
Lorenz JN; Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Lasko VM; Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Nieman ML; Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Jiang M; Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Gao X; Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Rubinstein J; Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Wieczorek DF; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Shull GE; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

J Mol Cell Cardiol ; 77: 53-63, 2014 Dec.

Article em En | MEDLINE | ID: mdl-25280781

Assuntos

Cardiomiopatia Hipertrófica/enzimologia; ATPases Transportadoras de Cálcio da Membrana Plasmática/genética; Tropomiosina/genética; Animais; Cardiomiopatia Hipertrófica/genética; Modelos Animais de Doenças; Expressão Gênica; Técnicas de Inativação de Genes; Frequência Cardíaca; Masculino; Camundongos Knockout; Miocárdio/metabolismo; Miocárdio/patologia; ATPases Transportadoras de Cálcio da Membrana Plasmática/metabolismo; Tropomiosina/metabolismo; Pressão Ventricular

Palavras-chave

Diastolic dysfunction; Diastolic properties; Hypertrophic cardiomyopathy; PMCA4; Pathological hypertrophy; Ventricular stiffness

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tropomiosina / Cardiomiopatia Hipertrófica / ATPases Transportadoras de Cálcio da Membrana Plasmática Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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