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Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists.
Moritomo, Ayako; Yamada, Hiroyoshi; Matsuzawa-Nomura, Takaho; Watanabe, Toshihiro; Itahana, Hirotsune; Oku, Makoto; Akuzawa, Shinobu; Okada, Minoru.
Afiliação
  • Moritomo A; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: ayako.moritomo@astellas.com.
  • Yamada H; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Matsuzawa-Nomura T; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Watanabe T; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Itahana H; Development, Astellas Pharma Inc., 2-5-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8411, Japan.
  • Oku M; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Akuzawa S; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Okada M; Process Chemistry Laboratories, Astellas Pharma Inc., 160-2 Akahama, Takahagi, Ibaraki 318-0001, Japan.
Bioorg Med Chem ; 22(21): 6026-38, 2014 Nov 01.
Article em En | MEDLINE | ID: mdl-25281269
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas da Serotonina / Receptores de Serotonina / Receptor 5-HT2B de Serotonina Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas da Serotonina / Receptores de Serotonina / Receptor 5-HT2B de Serotonina Idioma: En Ano de publicação: 2014 Tipo de documento: Article