Cellular senescence and the aging brain.
Exp Gerontol
; 68: 3-7, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25281806
ABSTRACT
Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors and proteases that have the potential to cause or exacerbate age-related pathology, both degenerative and hyperplastic. While cellular senescence in peripheral tissues has recently been linked to a number of age-related pathologies, its involvement in brain aging is just beginning to be explored. Recent data generated by several laboratories suggest that both aging and age-related neurodegenerative diseases are accompanied by an increase in SASP-expressing senescent cells of non-neuronal origin in the brain. Moreover, this increase correlates with neurodegeneration. Senescent cells in the brain could therefore constitute novel therapeutic targets for treating age-related neuropathologies.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Envelhecimento
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Senescência Celular
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article