The usefulness of the leuprolide stimulation test as a diagnostic method of idiopathic central precocious puberty in girls.
Horm Metab Res
; 46(13): 959-63, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25295414
ABSTRACT
Central precocious puberty (CPP) diagnosis is based on clinical evaluation, but hormonal evaluation is crucial. The aim of the study was to evaluate the usefulness of the leuprolide stimulation test for diagnosis of idiopathic CPP. Sixty-one girls, aged 5-8 years, were evaluated retrospectively for premature breast development. According to clinical evolution, 28 had progressive puberty and 33 nonprogressive puberty. All underwent a leuprolide stimulation test. Cutoff points, sensitivity, and specificity for gonadotropins and estradiol were determined by receiver operating characteristic (ROC) curves. Cutoff points for CPP were baseline LH > 0.1 mUI/l, FSH > 2.3 mUI/l, LH/FSH ratio > 0.23, estradiol > 12 pg/ml; and stimulated LH > 5.5 mUI/l, LH/FSH ratio > 0.24, estradiol > 79.67 pg/ml. The best diagnostic efficiency for progressive puberty were stimulated LH/FSH ratio (sensitivity 100%, specificity 94%) followed by stimulated LH (sensitivity 93%, specificity 100%). Stimulated LH/FSH ratio and LH resulted in the most useful parameters for the diagnosis of CPP. Stimulated estradiol did not add more information.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
/
Leuprolida
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article