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Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.
Rueli, Rachel H L H; Parubrub, Arlene C; Dewing, Andrea S T; Hashimoto, Ann C; Bellinger, Miyoko T; Weeber, Edwin J; Uyehara-Lock, Jane H; White, Lon R; Berry, Marla J; Bellinger, Frederick P.
Afiliação
  • Rueli RH; Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Parubrub AC; Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Dewing AS; Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Hashimoto AC; Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Bellinger MT; Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Weeber EJ; Molecular Pharmacology and Physiology, University of South Florida, Johnnie B. Byrd, Sr. Alzheimer's Center & Research Institute, Tampa, FL, USA.
  • Uyehara-Lock JH; Pathology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • White LR; Pacific Health Research and Education Institute, Honolulu, HI, USA.
  • Berry MJ; Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Bellinger FP; Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
J Alzheimers Dis ; 44(2): 379-83, 2015.
Article em En | MEDLINE | ID: mdl-25298198
ABSTRACT
Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Plexo Corióideo / Selenoproteína P / Doença de Alzheimer Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Plexo Corióideo / Selenoproteína P / Doença de Alzheimer Idioma: En Ano de publicação: 2015 Tipo de documento: Article