Organocatalytic enantioselective α-amination of 5-substituted rhodanines: an efficient approach to chiral N,S-acetals.
Org Biomol Chem
; 12(45): 9097-100, 2014 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-25298316
ABSTRACT
We report a highly efficient approach to constructing chiral N,S-acetals using 5-substituted rhodanines as sulfur-bound pronucleophiles catalyzed by natural cinchona alkaloids quinine or quinidine. This α-amination reaction has a broad substrate scope, and the products featuring both rhodanine and N,S-acetal structural motifs were obtained in high yields and excellent enantioselectivities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rodanina
/
Acetais
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article