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The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.
Jacobson, Richard; Mignemi, Nicholas; Rose, Kristie; O'Rear, Lynda; Sarilla, Suryakala; Hamm, Heidi E; Barnett, Joey V; Verhamme, Ingrid M; Schoenecker, Jonathan.
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  • Jacobson R; Vanderbilt University Medical Center, Department of Orthopaedics, 2200 Children's Way, Nashville, TN 37232-9565 United States; Vanderbilt University Medical Center, Department of Center for Bone Biology, 2200 Children's Way, Nashville, TN 37232-9565 United States; Vanderbilt University Medical Cente
  • Mignemi N; Vanderbilt University Medical Center, Department of Orthopaedics, 2200 Children's Way, Nashville, TN 37232-9565 United States; Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology, 2200 Children's Way, Nashville, TN 37232-9565 United States.
  • Rose K; Vanderbilt University, Mass Spectrometry Research Center, Proteomics Laboratory, Nashville, TN 37232 United States.
  • O'Rear L; Vanderbilt University Medical Center, Department of Orthopaedics, 2200 Children's Way, Nashville, TN 37232-9565 United States.
  • Sarilla S; Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology, 2200 Children's Way, Nashville, TN 37232-9565 United States.
  • Hamm HE; Vanderbilt University Medical Center, Department of Pharmacology, 2200 Children's Way, Nashville, TN 37232-9565 United States.
  • Barnett JV; Vanderbilt University Medical Center, Department of Pharmacology, 2200 Children's Way, Nashville, TN 37232-9565 United States.
  • Verhamme IM; Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology, 2200 Children's Way, Nashville, TN 37232-9565 United States.
  • Schoenecker J; Vanderbilt University Medical Center, Department of Orthopaedics, 2200 Children's Way, Nashville, TN 37232-9565 United States; Vanderbilt University Medical Center, Department of Center for Bone Biology, 2200 Children's Way, Nashville, TN 37232-9565 United States; Vanderbilt University Medical Cente
Thromb Res ; 134(6): 1350-7, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25307422
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aldeído Pirúvico / Coagulação Sanguínea / Heparina / Antitrombina III / Hiperglicemia Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aldeído Pirúvico / Coagulação Sanguínea / Heparina / Antitrombina III / Hiperglicemia Idioma: En Ano de publicação: 2014 Tipo de documento: Article