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Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer's disease.
Baddeley, Thomas C; McCaffrey, Jennifer; Storey, John M D; Cheung, John K S; Melis, Valeria; Horsley, David; Harrington, Charles R; Wischik, Claude M.
Afiliação
  • Baddeley TC; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.).
  • McCaffrey J; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.).
  • Storey JM; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.).
  • Cheung JK; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.).
  • Melis V; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.).
  • Horsley D; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.).
  • Harrington CR; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.).
  • Wischik CM; Department of Chemistry (T.C.B., J.M.D.S.), School of Medicine and Dentistry (J.K.S.C., V.M., D.H., C.R.H., C.M.W.),University of Aberdeen, Aberdeen, United Kingdom; and Salamandra LLC, Washington, DC (J.M.) cmw@taurx.com.
J Pharmacol Exp Ther ; 352(1): 110-8, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25320049
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer / Agregação Patológica de Proteínas / Azul de Metileno Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer / Agregação Patológica de Proteínas / Azul de Metileno Idioma: En Ano de publicação: 2015 Tipo de documento: Article