Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids.
Biotechnol Lett
; 37(2): 253-63, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25326172
ABSTRACT
Hairy root cultures of Rauwolfia serpentina induced by Agrobacterium rhizogenes have been investigated extensively for the production of terpenoid indole alkaloids. Various biotechnological developments, such as scaling up in bioreactors, pathway engineering etc., have been explored to improve their metabolite production potential. These hairy roots are competent for regenerating into complete plants and show survival and unaltered biosynthetic potential during storage at low temperature. This review provides a comprehensive account of the hairy root cultures of R. serpentina, their biosynthetic potential and various biotechnological methods used to explore the production of pharmaceutically important terpenoid indole alkaloids. The review also indicates how biotechnological endeavors might improve the future progress of research for production of alkaloids using Rauwolfia hairy roots.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rauwolfia
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Raízes de Plantas
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Reatores Biológicos
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Alcaloides de Triptamina e Secologanina
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Técnicas de Cultura de Tecidos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article