Periprocedural complications and long-term outcome after alcohol septal ablation versus surgical myectomy in hypertrophic obstructive cardiomyopathy: a single-center experience.
JACC Cardiovasc Interv
; 7(11): 1227-34, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25326737
ABSTRACT
OBJECTIVES:
This study compared alcohol septal ablation (ASA) and surgical myectomy for periprocedural complications and long-term clinical outcome in patients with symptomatic hypertrophic obstructive cardiomyopathy.BACKGROUND:
Debate remains whether ASA is equally effective and safe compared with myectomy.METHODS:
All procedures performed between 1981 and 2010 were evaluated for periprocedural complications and long-term clinical outcome. The primary endpoint was all-cause mortality; secondary endpoints consisted of annual cardiac mortality, New York Heart Association functional class, rehospitalization for heart failure, reintervention, cerebrovascular accident, and myocardial infarction.RESULTS:
A total of 161 patients after ASA and 102 patients after myectomy were compared during a maximal follow-up period of 11 years. The periprocedural (30-day) complication frequency after ASA was lower compared with myectomy (14% vs. 27%, p = 0.006), and median duration of in-hospital stay was shorter (5 days [interquartle range (IQR) 4 to 6 days] vs. 9 days [IQR 6 to 12 days], p < 0.001). After ASA, provoked gradients were higher compared with myectomy (19 [IQR 10 to 42] vs. 10 [IQR 7 to 13], p < 0.001). After multivariate analysis, age (per 5 years) (hazard ratio 1.34 [95% confidence interval 1.08 to 1.65], p = 0.007) was the only independent predictor for all-cause mortality. Annual cardiac mortality after ASA and myectomy was comparable (0.7% vs. 1.4%, p = 0.15). During follow-up, no significant differences were found in symptomatic status, rehospitalization for heart failure, reintervention, cerebrovascular accident, or myocardial infarction between both groups.CONCLUSIONS:
Survival and clinical outcome were good and comparable after ASA and myectomy. More periprocedural complications and longer duration of hospital stay after myectomy were offset by higher gradients after ASA.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cardiomiopatia Hipertrófica
/
Etanol
/
Técnicas de Ablação
/
Procedimentos Cirúrgicos Cardíacos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article