Convenient detection of metal-DNA, metal-RNA, and metal-protein adducts with a click-modified Pt(II) complex.
Dalton Trans
; 44(8): 3536-9, 2015 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-25338004
ABSTRACT
cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA. Pt-protein adducts are detected using BSA as a model. Following in vivo treatment, long-lived Pt-RNA adducts are detected on ribosomal RNA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Platina
/
DNA
/
RNA
/
Proteínas
/
Complexos de Coordenação
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article