[GSTP1 Ile105Val polymorphism confer susceptibility to oral cancer:a meta-analysis].

ABSTRACT

PURPOSE: This meta-analysis was aimed to evaluate the association of glutathione S-transferase P1 (GSTP1) Ile105Val genetic polymorphism with susceptibility to oral cancer. METHODS: A literature search of PubMed, Chinese BioMedical, Wanfang, VIP, CNKI databases was conducted from inception to July 15th, 2013. Crude odd ration (OR) with 95% confidence intervals (CI) was calculated. RESULTS: Thirteen case-control studies were assessed, including 2,019 oral cancer patients and 3,282 healthy controls. Meta-analysis showed that the overall association between GSTP1 Ile105Val polymorphism and susceptibility to oral cancer was not significant. However, further stratified analyses based on ethnicity indicated that this association was significant in East Asians (Val vs. Ile OR=1.42, 95%CI 1.06-1.90, P=0.019; Val/Val+Ile/Val vs. Ile/Ile OR=1.59, 95%CI 1.13-2.23, P=0.007) and Euro Caucasians (Val vs. Ile OR=1.34, 95%CI 1.03-1.75, P=0.032; Val/Val+Ile/Val vs. Ile/Ile OR=1.66, 95%CI 1.15-2.38, P=0.006), but not significant in South Asians and America Caucasians. CONCLUSIONS: This meta-analysis provides further evidence that GSTP1 Ile105Val polymorphism may be associated with oral cancer risk among East Asians and Euro Caucasians. However, further large-scale studies are needed to determine the association of GSTP1 Ile105Val genetic polymorphism with susceptibility to oral cancer.