A French multicentric study and review of pulmonary Nocardia spp. in cystic fibrosis patients.
Med Microbiol Immunol
; 204(4): 493-504, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25344657
ABSTRACT
Some bacterial species recovered from the airways of cystic fibrosis (CF) patients are indisputably associated with lung infections, whereas the clinical relevance of others, such as Nocardia spp., remains unclear. Sixteen French CF cases of colonization/infection with Nocardia spp. were reviewed in order to evaluate the epidemiology, the clinical impact and the potential treatment of these bacteria, and results were compared to those of the literature. Five Nocardia species were identified, Nocardia cyriacigeorgica being the major species (50 % of cases). At first isolation, Nocardia was the sole pathogen recovered in six patients. Seven patients presented pulmonary exacerbation. For 12 patients, antimicrobial treatment against Nocardia was started immediately, mainly based on cotrimoxazole (6 of the 12 cases). In this study, we highlight the heterogeneity of the clinical management of Nocardia spp. in CF. Guidelines for the clinical management of Nocardia infections in CF patients are proposed.
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Base de dados:
MEDLINE
Assunto principal:
Portador Sadio
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Pneumonia Bacteriana
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Fibrose Cística
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Nocardia
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Nocardiose
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article