4-amino-substituted benzenesulfonamides as inhibitors of human carbonic anhydrases.
Molecules
; 19(11): 17356-80, 2014 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-25353386
ABSTRACT
A series of N-aryl-ß-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay and isothermal titration calorimetry. The results showed that 4-substituted diazobenzenesulfonamides were more potent CA binders than N-aryl-ß-alanine derivatives. Most of the N-aryl-ß-alanine derivatives showed better affinity for CA II while diazobenzenesulfonamides possessed nanomolar affinities towards CA I isozyme. X-ray crystallographic structures showed the modes of binding of both compound groups.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Anidrases Carbônicas
/
Compostos de Diazônio
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article