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Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
Henderson, Jaclyn L; Kormos, Bethany L; Hayward, Matthew M; Coffman, Karen J; Jasti, Jayasankar; Kurumbail, Ravi G; Wager, Travis T; Verhoest, Patrick R; Noell, G Stephen; Chen, Yi; Needle, Elie; Berger, Zdenek; Steyn, Stefanus J; Houle, Christopher; Hirst, Warren D; Galatsis, Paul.
Afiliação
  • Henderson JL; Worldwide Medicinal Chemistry, ‡Neuroscience Research Unit, and §Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 58(1): 419-32, 2015 Jan 08.
Article em En | MEDLINE | ID: mdl-25353650

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Proteínas Serina-Treonina Quinases / Proteoma / Inibidores de Proteínas Quinases / Nitrilas Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Proteínas Serina-Treonina Quinases / Proteoma / Inibidores de Proteínas Quinases / Nitrilas Idioma: En Ano de publicação: 2015 Tipo de documento: Article